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Transforming Heart Health

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  3. Fernández-Vizarra, E., Enríquez, J.A., Pérez-Martos, A., Montoya, J., & Fernández-Silva, P. (2011). Tissue-specific differences in mitochondrial activity and biogenesis. Mitochondrion, 11(1), 207–213.
  4. Veltri, K.L., Espiritu, M., & Singh, G. (1990). Distinct genomic copy number in mitochondria of different mammalian organs. Journal of Cell Physiology, 143(1), 160–164.
  5. Li, Q., Heaney, A., Langenfeld-McCoy, N., Boler, B. V., & Laflamme, D. P. (2019). Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Veterinary Research, 15(1), 425.

Nutrition and Heart Health

  1. Doenst, T., Nguyen, T. D., & Abel, E. D. (2013). Cardiac metabolism in heart failure: implications beyond ATP production. Circulation Research, 113(6), 709–724.
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  3. Lopaschuk, G. (2017). Metabolic Modulators in Heart Disease: Past, Present, and Future. Canadian Journal of Cardiology, 33, 838–849.
  4. Labarthe, F., Gélinas, R., & Des Rosiers, C. (2008). Medium-chain fatty acids as metabolic therapy in cardiac disease. Cardiovascular Drugs and Therapy, 22(2), 97–106.
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  12. Freeman, L.M. (2010). Beneficial effects of omega-3 fatty acids in cardiovascular disease. Journal of Small Animal Practice, 51(9), 462–470.
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  23. Sanderson S. L. (2006). Taurine and carnitine in canine cardiomyopathy. The Veterinary Clinics of North America. Small Animal Practice, 36(6), 1325–viii.
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  32. Sozen, E., Demirel, T., & Ozer, N.K. (2019). Vitamin E: regulatory role in the cardiovascular system. International Union of Biochemistry and Molecular Biology Life, 71(4), 507–515.
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  34. Freeman, L.M., Rush, J.E., & Markwell, P.J. (2006). Effects of dietary modification in dogs with early chronic valvular disease. Journal of Veterinary Internal Medicine, 20, 1116–1126.
  35. Qu, X., Jin, F., Hao, Y., Li, H., Tang, T., Wang, H., Yan, W., & Dai, K. (2013). Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies. PloS one, 8(3), e57720.
  36. Tardy, A.L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1). pii: E228.
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Cardiac Conditions - Introduction

  1. Keene, B. W., Atkins, C. E., Bonagura, J. D., Fox, P. R., Häggström, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., & Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine, 33(3), 1127–1140.
  2. Buchanan, J.W. Prevalence of cardiovascular disorders. In: Fox P.R, Sisson D.D, Moise N.S, editors. Textbook of Canine and Feline Cardiology: Principles and Clinical Practice. 2nd ed. Philadelphia, PA: WB Saunders; 1999. pp. 457–470.
  3. Payne, J. R., Brodbelt, D. C., & Luis Fuentes, V. (2015). Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study). Journal of Veterinary Cardiology: the official journal of the European Society of Veterinary Cardiology, 17 Suppl 1, S244–S257.
  4. Fox, P. R., Keene, B. W., Lamb, K., Schober, K. A., Chetboul, V., Luis Fuentes, V., … Tachika Ohara, V. Y. (2018). International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study. Journal of Veterinary Internal Medicine, 32(3), 930–943.
  5. Côté, E., Edwards, N.J., Ettinger, S.J., Fuentes, V.L., MacDonald, K.A., Scansen, B.A., Sisson, D.D., & Abbott, J.A. (2015). Management of incidentally detected heart murmurs in dogs and cats. Journal of Veterinary Cardiology, 17(4), 245–261.
  6. Loughran, K. A., Rush, J. E., Rozanski, E. A., Oyama, M. A., Larouche-Lebel, É., & Kraus, M. S. (2019). The use of focused cardiac ultrasound to screen for occult heart disease in asymptomatic cats. Journal of Veterinary Internal Medicine, 33(5), 1892–1901.
  7. Luis Fuentes, V., Abbott, J., Chetboul, V., Côté, E., Fox, P. R., Häggström, J., Kittleson, M. D., Schober, K., & Stern, J. A. (2020). ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats. Journal of Veterinary Internal Medicine, 34(3), 1062–1077.
  8. Borgarelli, M., & Buchanan, J.W. (2012). Historical review, epidemiology and natural history of degenerative mitral valve disease. Journal of Veterinary Cardiology, 14(1), 93–101.
  9. Rush, J. E., Freeman, L. M., Fenollosa, N. K., & Brown, D. J. (2002). Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990–1999). Journal of the American Veterinary Medical Association, 220(2), 202–207.
  10. MacDonald, K. Feline cardiomyopathy. In: Smith, F.W.K., Tilley, L.P., Oyama, M.A., & Sleeper, M.M, editors. Manual of Canine and Feline Cardiology. 5th ed. Saint Louis, MO: Elsevier; 2016. pp. 153.
  11. Schrope, D. P. (2015). Prevalence of congenital heart disease in 76,301 mixed-breed dogs and 57,025 mixed-breed cats. Journal of Veterinary Cardiology: the official journal of the European Society of Veterinary Cardiology, 17(3), 192–202.
  12. Gil-Ortuño, C., Sebastián-Marcos, P., Sabater-Molina, M., Nicolas-Rocamora, E., Gimeno-Blanes, J. R., & Fernández Del Palacio, M. J. (2020). Genetics of feline hypertrophic cardiomyopathy. Clinical Genetics, 10.1111/cge.13743.
  13. Freeman, L. M. & Rush, J. Nutrition in Cardiovascular Disorders. In: Smith, F.W.K., Tilley, L.P., Oyama, M.A., & Sleeper, M.M, editors. Manual of Canine and Feline Cardiology. 5th ed. Saint Louis, MO.: Elsevier; 2016. Pp. 394–403.
  14. Ettinger, S. J., Benitz, A. M., Ericsson, G. F., Cifelli, S., Jernigan, A. D., Longhofer, S. L., Trimboli, W., & Hanson, P. D. (1998). Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. The Long-Term Investigation of Veterinary Enalapril (LIVE) Study Group. Journal of the American Veterinary Medical Association, 213(11), 1573–1577.
  15. Häggström, J., Boswood, A., O'Grady, M., Jöns, O., Smith, S., Swift, S., … DiFruscia, R. (2008). Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study. Journal of Veterinary Internal Medicine, 22(5), 1124–1135.
  16. Mattin, M. J., Boswood, A., Church, D. B., McGreevy, P. D., O'Neill, D. G., Thomson, P. C., & Brodbelt, D. C. (2015). Degenerative mitral valve disease: Survival of dogs attending primary-care practice in England. Preventive Veterinary Medicine, 122(4), 436–442.
  17. Li, Q., Freeman, L. M., Rush, J. E., & Laflamme, D. P. (2015). Expression Profiling of Circulating MicroRNAs in Canine Myxomatous Mitral Valve Disease. International Journal of Molecular Sciences, 16(6), 14098–14108.

Cardiac Conditions - Heart Failure

  1. Keene, B. W., Atkins, C. E., Bonagura, J. D., Fox, P. R., Häggström, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., & Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine, 33(3), 1127–1140.
  2. Neubauer, S. (2007). The failing heart – an engine out of fuel. The New England Journal of Medicine, 356(11), 1140–1151.
  3. Lopaschuk, G. (2017). Metabolic Modulators in Heart Disease: Past, Present, and Future. Canadian Journal of Cardiology, 33, 838–849.
  4. Sabbah, H. N. (2020). Targeting the Mitochondria in Heart Failure: A Translational Perspective. JACC. Basic to Translational Science, 5(1), 88–106.
  5. Taegtmeyer, H. (2004). Cardiac metabolism as a target for the treatment of heart failure. Circulation,110(8), 894–896.
  6. Doenst, T., Nguyen, T. D., & Abel, E. D. (2013). Cardiac metabolism in heart failure: implications beyond ATP production. Circulation Research, 113(6), 709–724.
  7. Karwi, Q. G., Uddin, G. M., Ho, K. L., & Lopaschuk, G. D. (2018). Loss of Metabolic Flexibility in the Failing Heart. Frontiers in Cardiovascular Medicine, 5, 68.
  8. Li, Q., Freeman, L. M., Rush, J. E., Huggins, G. S., Kennedy, A.D., Labuda, J.A., Laflamme, D.P., & Hannah, S.S. (2015). Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. OMICS, 19(8), 461–470.
  9. Jiang, L., Wang, J., Li, R., Fang, Z.M., Zhu, X.H., Yi, X., ... Jiang, D.S. (2019). Disturbed energy and amino acid metabolism with their diagnostic potential in mitral valve disease revealed by untargeted plasma metabolic profiling. Metabolomics, 15(4), 57.
  10. Lanfear, D. E., Gibbs, J. J., Li, J., She, R., Petucci, C., Culver, J. A., … Gardell, S. J. (2017). Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients. Journal of the American College of Cardiology,Heart failure, 5(11), 823–832.
  11. Oyama, M. A., & Chittur, S. V. (2006). Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease. American Journal of Veterinary Research, 67(8), 1307–1318.
  12. Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., … Gheorghiade, M. (2017). Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nature reviews. Cardiology, 14(4), 238–250.

Cardiac Conditions - MMVD

  1. Buchanan, J.W. (1977). Chronic valvular disease (endocardiosis) in dogs. Advances in Veterinary Science, 21, 57–106.  
  2. Detweiler, D. K., & Patterson, D. F. (1965). The prevalence and types of cardiovascular disease in dogs. Annals of the New York Academy of Sciences, 127(1), 481–516.
  3. Haggstrom, J., Kvart, C., & Pedersen, H.D. (2005). Acquired valvular disease. In: Ettinger, S.J., Feldman, E.C., eds. Textbook of Veterinary Internal Medicine, 6th ed. St Louis: Elsevier: 1022–1039.
  4. Keene, B. W., Atkins, C. E., Bonagura, J. D., Fox, P. R., Häggström, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., & Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine, 33(3), 1127–1140.
  5. Atkins, C., Bonagura, J., Ettinger, S., Fox, P., Gordon, S., Haggstrom, J., … Stepien R. (2009). Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. Journal of Veterinary Internal Medicine, 23, 1142–1150.
  6. Borgarelli, M., & Buchanan, J.W. (2012). Historical review, epidemiology and natural history of degenerative mitral valve disease. Journal of Veterinary Cardiology, 14(1), 93–101.
  7. Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., … Gheorghiade, M. (2017). Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nature reviews. Cardiology, 14(4), 238–250.
  8. Lopaschuk, G. (2017). Metabolic Modulators in Heart Disease: Past, Present, and Future. Canadian Journal of Cardiology, 33, 838–849.
  9. Sabbah, H. N. (2020). Targeting the Mitochondria in Heart Failure: A Translational Perspective. JACC. Basic to Translational Science, 5(1), 88–106.
  10. Li, Q., Freeman, L.M., Rush, J.E., Huggins, G.S., Kennedy, A.D., Labuda, J.A., Laflamme, D.P., & Hannah, S.S. (2015). Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. OMICS, 19(8), 461–470.
  11. Li, Q., Heaney, A., Langenfeld-McCoy, N., Boler, B. V., & Laflamme, D. P. (2019). Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs. BMC Veterinary Research, 15(1), 425.
  12. Dickson, D., Caivano, D., Matos, J.N., Summerfield, N., & Rishniw, M. (2017). Two dimensional echocardiographic estimates of left atrial function in healthy dogs and dogs with myxomatous mitral valve disease. Journal of Veterinary Cardiology, 19, 469–479.
  13. Li, Q., Laflamme, D.P., & Bauer, J. E. (2020). Serum untargeted metabolomic changes in response to dietary intervention on dogs with preclinical myxomatous mitral valve disease. PLoS One, 15(6), 0234404.

Emerging Science - Heart-Gut Axis

  1. Jin, M., Qian, Z., Yin, J., Xu, W., & Zhou, X. (2019). The role of intestinal microbiota in cardiovascular disease. Journal of Cellular and Molecular Medicine, 23(4), 2343–2350.
  2. Kamo, T., Akazawa, H., Suzuki, J. I., & Komuro, I. (2017). Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure. Korean Circulation Journal, 47(5), 663–669.
  3. Tang, W., Li, D. Y., & Hazen, S. L. (2019). Dietary metabolism, the gut microbiome, and heart failure. Nature reviews. Cardiology, 16(3), 137–154.
  4. Wang, Z., Liu, Y., Liu, G., Lu, H., Mao, C. (2018). L-Carnitine and heart disease. Life Sciences, 184, 88–97.
  5. Zhao, Y., & Wang, Z. (2020). Gut microbiome and cardiovascular disease. Current Opinion in Cardiology, 35(3), 207–218.
  6. Luedde, M., Winkler, T., Heinsen, F. A., Rühlemann, M. C., Spehlmann, M. E., Bajrovic, A., Lieb, W., Franke, A., Ott, S. J., & Frey, N. (2017). Heart failure is associated with depletion of core intestinal microbiota. ESC heart failure, 4(3), 282–290.
  7. Coelho, L. P., Kultima, J. R., Costea, P. I., Fournier, C., Pan, Y., Czarnecki-Maulden, G., Hayward, M. R., Forslund, S. K., Schmidt, T., Descombes, P., Jackson, J. R., Li, Q., & Bork, P. (2018). Similarity of the dog and human gut microbiomes in gene content and response to diet. Microbiome, 6(1), 72.

Emerging Science - Omics

  1. Civelek, M., & Lusis, A. J. (2014). Systems genetics approaches to understand complex traits. Nature reviews. Genetics, 15(1), 34–48.
  2. Hasin, Y., Seldin, M., & Lusis, A. (2017). Multi-omics approaches to disease. Genome biology, 18(1), 83.
  3. Kato, H., Takahashi, S., & Saito, K. (2011). Omics and integrated omics for the promotion of food and nutrition science. Journal of Traditional and Complementary Medicine, 1(1), 25–30.
  4. Li, Q., Freeman, L.M., Rush, J.E., Huggins, G.S., Kennedy, A.D., Labuda, J.A., Laflamme, D.P., & Hannah, S.S. (2015). Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs. OMICS, 19(8), 461–470.